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4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide

Avanafil

CAS: 330784-47-9

Molecular Formula: C23H26ClN7O3

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  5. 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide

4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide - Names and Identifiers

Name Avanafil
Synonyms vanafil
avanfil
Avanafil
Avanafil PDE5 inhibitor
(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl
(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine
4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
CAS 330784-47-9
EINECS 000-000-0
InChI InChI=1/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1

4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide - Physico-chemical Properties

Molecular FormulaC23H26ClN7O3
Molar Mass483.95
Density1.372
Melting Point150-152°C
Solubility DMSO 97 mg/mL (200 mM) Water <1 mg/mL (<1 mM) Ethanol <1 mg/mL (<1 mM) , DMSO 97 m
AppearanceSolid
ColorWhite to Off-White
pKa11.84±0.46(Predicted)
Storage ConditionSealed in dry,Store in freezer, under -20°C
Refractive Index1.651
In vivo studyAvanafil (I. V.) promotes penile erection and ED200% in dogs is 37.5 μg/kg. In addition, intraduodenal treatment with Avanafil enhanced pelvic nerve stimulation-induced penile intracavernous pressure and duration. Injections of Avanafil(1 μm) in the cavernous body of T2DM rats caused local improvement in the erectile response.

4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide - Risk and Safety

HS Code29339900

4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide - Introduction

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
Last Update：2022-10-16 17:24:39
4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
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Shanghai Worldyang Chemical Co.,Ltd.
Featured Products
Product Name: Avanafil Request for quotation
CAS: 330784-47-9
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
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CAS: 330784-47-9
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Product Name: Avanafil Visit Supplier Webpage Request for quotation
CAS: 330784-47-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Avanafil Visit Supplier Webpage Request for quotation
CAS: 330784-47-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Avanafil Visit Supplier Webpage Request for quotation
CAS: 330784-47-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Avanafil Visit Supplier Webpage Request for quotation
CAS: 330784-47-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
Loratadine Impurity 72
3-Penten-2-one, (3E)-
3,6,9-Trioxadecanoic acid (TODS)
ene)Bis(2-MethyL
3-Azabicyclo[3.1.0]hexane-6-carboxylic acid, 2,4-dioxo-3-[3-(trifluoromethyl)phenyl]-, ethyl ester
2-[(2-chloro-4-nitrophenyl)thio]ethanohydrazide
2-Azaspiro[3.3]heptane-1-carboxylic acid hydrochloride
4-bicyclo[2.2.1]hept-2-yl-3-methyl-3-buten-2-one
4-NITROCATECHOL
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